BIO 381 Pathophysiology

WEEK 1. INNATE IMMUNITY AND INFLAMMATION1.1. Innate Immunity1.1.1. The First Line of Defense1.2. The Second Line of Defense – Inflammation and Complement System1.2.1. Characteristics of Inflammation1.2.2. The Inflammatory Response1.2.3. Drugs for Inflammation and Dietary Contributions1.2.4. The Complement SystemWEEK 2. ADAPTIVE IMMUNITY, LEUKEMIA, AND OTHER BLOOD CELL PATHOLOGIES2.1. Adaptive Immunity2.1.1. Lymphoid Tissue2.1.2. Thymic Selection2.1.3. Antigens and Antigen Processing2.1.4. Humoral Immunity 2.1.5. Cell-Mediated Immunity 2.1.6. Type I Hypersensitivity2.1.7. Type II Hypersensitivity 2.1.8. Type III Hypersensitivity2.1.9. Type IV Hypersensitivity2.2. Neutropenia, Mononucleosis, Leukemia and Lymphoma 2.2.1. Hematopoiesis and Colony-Stimulating Factors2.2.2. Neutropenia2.2.3. Infectious Mononucleosis 2.2.4. Leukemia 2.2.5. Lymphoma2.2.6. Multiple Myeloma WEEK 3. HEMOSTASIS AND RED BLOOD CELLS3.1. Hemostasis3.1.1. Healthy Endothelium – Endogenous Antiplatelets and Anticoagulants3.1.2. The Stages of Hemostasis3.1.3. Inherited (Primary) Disorders NOT Involving Platelets3.1.4. Inherited (Primary) Disorders Involving Platelets3.1.5. Acquired (Secondary) Disorders NOT Directly Involving Platelets3.1.6. Acquired (Secondary) Disorders Directly Involving Platelets3.2. Red Blood Cells3.2.1. Hemoglobin and the Breakdown of Hemoglobin3.2.2. Important Red Blood Cell Lab Tests3.2.3. Disorders of the Red Blood Cell Membrane 3.2.4. Types of Thalassemia3.2.5. Role of Iron and Iron Deficiency Anemia3.2.6. Megaloblastic Anemias3.2.7. Aplastic and Chronic Disease Anemia3.2.8. Polycythemia WEEK 4. CARDIOVASCULAR SYSTEM4.1. Disorders of Blood Vessels4.1.1. Lipid and Lipoprotein Processing4.1.2. Atherosclerosis4.1.3. Hypertension 4.1.4. Hypotension4.1.5. Disorders of Venous Circulation 4.1.6. Disorders of Arterial Circulation 4.2. Disorders of the Heart4.2.1. Infective Endocarditis4.2.2. Rheumatic Heart Disease 4.2.3. Cardiomyopathies 4.2.4. Heart Failure4.2.5. ShockWEEK 5. ENDOCRINE DISORDERS5.1. Endocrine Disorders (Adenomas, Prolactin, Growth Hormone, and Thyroid Hormone)5.1.1. Hypothalamic-Pituitary Regulation5.1.2. Pituitary Adenomas5.1.3. Prolactin (PRL) Disorders5.1.4. Growth Hormone Disorders5.1.5. Thyroid Hormone Disorders5.2. Endocrine Disorders (Aldosterone, Cortisol, and ADH)5.2.1. Adrenal Gland5.2.2. Aldosterone (Mineralocorticoid)5.2.3. Cortisol (Glucocorticoids)5.2.4. Anti-Diuretic Hormone (ADH)WEEK 6. NEUROLOGICAL DISORDERS6.1. Disorders of Neuromuscular Function 6.1.1. Muscular Dystrophy6.1.2. Disorders of the Neuromuscular Junction6.1.3. Polyneuropathies and Guillain-Barre Syndrome6.1.4. Parkinson’s Disease (PD)6.1.5. Amyotrophic Lateral Sclerosis (ALS)6.1.6. Multiple Sclerosis (MS)6.2. Disorders of Brain Function 6.2.1. Stroke6.2.2. Meningitis and Encephalitis6.2.3. Seizures6.2.4. Dementia and Alzheimer’s Disease6.2.5. NarcolepsyWEEK 7. MIDTERM EXAMWEEK 8. DISORDERS OF GI FUNCTION8.1. Disorders of GI Function Part I 8.1.1. GI Tract Anatomy8.1.2. Irritable Bowel Syndrome (IBS)8.1.3. Inflammatory Bowel Disease8.1.4. Infectious Enterocolitis8.1.5. Clostridium difficile Colitis8.1.6. E. Coli 0157:H7 and HUS8.2. Disorders of GI Function Part II8.2.1. Diverticular Disease8.2.2. Intestinal Obstruction8.2.3. GI Issues Involving Gluten8.2.4. Disorders of the Esophagus8.2.5. Gastroesophageal Reflux Disease (GERD)8.2.6. Gastritis8.2.7. Peptic UlcersWEEK 9. RESPIRATORY DISORDERS9.1. Disorders of Respiratory Function Part I 9.1.1. Disorders of the Pleura9.1.2. Pneumothorax9.1.3. Atelectasis9.1.4. Asthma9.2. Disorders of Respiratory Function Part II9.2.1. Chronic Obstructive Pulmonary Disease (COPD) 9.2.2. The Common Cold and Rhinosinusitis9.2.3. Influenza9.2.4. Pneumonia9.2.5. Tuberculosis (TB)WEEK 10. SKELETAL, VISION, AND HEARING DISORDERS10.1. Disorders of the Skeletal System 10.1.1. Mechanisms of Bone Remodeling10.1.2. Osteopenia and Osteoporosis10.1.3. Osteomalacia, Rickets, and Paget’s Disease10.1.4. Osteoarthritis (OA)10.1.5. Rheumatoid Arthritis (RA)10.1.6. Gout10.2. Vision and Hearing Disorders 10.2.1. Conjunctivitis10.2.2. The Retina, Retinopathies, and Retinal Detachment10.2.3. Macular Degeneration10.2.4. Glaucoma10.2.5. Disorders of the Lens10.2.6. Disorders of Neural Pathways10.2.7. Disorders of the Ear - Otitis10.2.8. Disorders of the Ear - Otosclerosis, Tinnitus, and Hearing LossWEEK 11. PAIN, HEADACHE, AND REPRODUCTIVE SYSTEM DISORDERS11.1. Pain and Headaches 11.1.1. Introduction to Pain and Pain Assessments11.1.2. Pain Transduction11.1.3. Pain Transmission11.1.4. Pain Perception11.1.5. Pain Modulation11.1.6. The Gate-Control Theory of Pain11.1.7. Types of Pain11.1.8. Pain Medication11.1.9. Headaches11.2. Reproductive System Disorders11.2.1. Benign Prostatic Hyperplasia and Prostate Cancer11.2.2. Disorders of the Uterus11.2.3. Review of the Physiology of the Menstrual Cycle11.2.4. Disorders of the Ovary11.2.5. Breast Structures and Breast CancerWEEK 12. RENAL DISORDERS 12.1. Renal Dysfunctions, PKD, Nephrotic and Nephritic Syndromes, and Obstructive Disorders12.1.1. Polycystic Kidney Disease (PKD)12.1.2. Disorders of the Glomerulus12.1.3. Obstructive Disorders and Kidney Stones12.2. Kidney Functions Tests, UTI and AKI12.2.1. Kidney Function Tests12.2.2. Urinary Tract Infection (UTI)12.2.3. Acute Kidney Injury (AKI)

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