• BIO 461 Principles of Physiology
  • Module 1.0. Homeostasis, Membranes, Electrophysiology and ANS
  • Module 2.0. Skeletal Muscle and Special Senses
  • Module 3.0. Cardiovascular System
  • Module 4.0. Urinary and Respiratory Systems
  • Module 5.0. Digestive, Endocrine and Reproductive Systems
  • Appendix A. Gender
  • Appendix B. The Placebo Effect
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  • 3.1.1

    Chambers and Circulation

    The heart is composed of two pumps. The right side of the heart receives oxygen-poor blood, known as deoxygenated blood, from the systemic circulation and pumps the blood to the lungs where oxygen and carbon dioxide are exchanged. The left side receives oxygen-rich, known as oxygenated blood, from the lungs and pumps it to the rest of the body. These two circulations are referred to as the pulmonary circulation (to the lungs) and the systemic circulation (to the rest of the body), respectively.

    Systemic and Pulmonary Circulation.
     Image created by BYU-Idaho student Tabitha Daughtery Spring 2014
    Image created by BYU-Idaho student Nate Shoemaker Winter 2016
    Aortic semilunar valves
    Image by BYU-I Student Becky Torgerson – S18

    Notice how coronary arteries receive blood during diastole.  During systole, the blood opens the semilunar valves and rushes through. Blood does not easily enter the coronary vessels easily during systole.

    Heart Chambers  

    Mammalian hearts have four chambers, two receiving chambers called atria and two pumping chambers called ventricles.  The right side of the heart is separated from the left side of the heart by a thick wall known as the septum. The right atrium receives oxygen-poor blood from the systemic circulation and the left atrium receives oxygen-rich blood from the pulmonary circulation. Blood from the right atrium enters the right ventricle, which then pumps the blood to the lungs. The right side of the heart is a low-pressure system and seldom produces pressures above 40 mmHg. Blood from the left atrium enters the left ventricle, which pumps the blood to the systemic circulation. Blood is pumped through the systemic circulation starting at the aorta, a major artery in the body. Branching immediately from the aorta are two smaller arteries called coronary arteries (See image above). These arteries supply the heart with oxygen-rich blood. The left side of the heart is a high-pressure system and routinely produces pressures of around 120 mmHg and during times of physical stress can generate pressures over 200 mmHg.

    Heart Valves (See Images above)

    To ensure that the blood moves efficiently through the heart, two sets of one-way valves prevent the blood from flowing backward. The atrioventricular (AV) valves are located between the atria and the ventricles. Between the right atrium and right ventricle is the right AV or tricuspid valve and between the left atrium and left ventricle is the left AV, the bicuspid or the mitral valve. The names bi- and tricuspid are derived from the number of cusps or flaps that make up the valve. A closer look at these valves reveals that they are supported by small tendon-like attachments called chordae tendineae, which attach the edges of the valves to small nipple-like projections of muscle called papillary muscles. This arrangement prevents the valves from pushing back into the atria when the ventricles contract, a condition known as prolapse of the valve.

    The semilunar valves are located between the ventricles and the large arteries that receive blood from them. Between the right ventricle and the pulmonary trunk is the pulmonary semilunar valve or simply pulmonary valve, and between the left ventricle and the aorta is the aortic semilunar valve or aortic valve. The structure of these valves is different from the AV valves. Each valve is composed of three pocket-like structures. When blood from the large arteries moves back toward the ventricles, these valves balloon out like small parachutes. Their three cusps come together preventing blood from moving backward.

    Heart Murmurs

    Heart murmurs can be caused by improperly functioning heart valves. There are two basic types of problems that can occur. The valve may become stiff and not open properly. This is referred to as valvular stenosis. The stenotic valve creates turbulent flow as the blood passes through which creates a sound or murmur that can be detected with a stethoscope (The art of listening to body sounds via a stethoscope is called auscultation). Conversely, the valve may not close properly and blood will backflow through the valve. This is referred to as valvular regurgitation. Again, the backflow of blood creates turbulent flow, generating a detectable murmur. Not all murmurs are due to valve disease. It is not uncommon to detect murmurs in young, thin individuals or during times of greatly increased blood flow as would occur during strenuous physical activity. These murmurs are considered normal and do not pose a risk to the individuals. Valvular disease, on the other hand, increases the workload on the heart and if severe and not treated can lead to heart failure. Historically, it was a fine art to detect the type of valvular abnormality based on the sound and timing of the murmur. Modern technology, such as cardiac ultrasonography, has made it much easier to determine the nature of the valvular disease and determine the proper course of treatment.

    Cardiac muscle cells are much smaller than skeletal muscle cells and they are branched. In addition, cardiac muscle cells are connected end-to-end by special structures called intercalated discs (in-ter’kă-lā-ted). Located on the intercalated discs are different types of cell junctions that are part of keeping communication open between the cells. These are desmosomes, and gap junctions.

    Cell Junctions.
     Author: John W. Kimball. Site: http://www.biology-pages.info/C/CellJunctions.gif License: CC BY 3.0

    Desmosomes tightly connect the cells together. Recall that skeletal muscle attaches to bone via tendons so that when it contracts, it pulls on the bones generating movement. Cardiac muscle cells, on the other hand, do not connect to anything except other cardiac muscle cells. When cardiac muscle contracts, the desmosomes all pull against each other causing the diameter of the chambers to decrease, which generates the pressure necessary to pump the blood.

    The intercalated disks also contain gap junctions which allow communication between the connected cells. This allows movement of cytoplasm, including ions, between the cells, effectively lowering the resistance, and more importantly, this allows action potentials to spread from one cell to the next. The gap junctions along with the intricate branching of the muscle cells allow an electrical signal to spread from cell-to-cell resulting in contraction of the entire heart. Hence, even though there are millions of cells in each chamber, functionally they act as a single cell. This arrangement is referred to as a functional syncytium (syn = together; cyt = cell).

    Other differences between cardiac and skeletal muscle include the following:

    Cardiac Sarcomere
    Author: Richard E. Klabunde. Site: https://books.byui.edu/-tEKL LicenseCC BY-NC-SA 4.0. Permission kindly granted by the author in February of 2017 for use.

    This content is provided to you freely by BYU-I Books.

    Access it online or download it at https://books.byui.edu/bio_461_principles_o/chambers_and_circula.