CoverModule 1.0. Homeostasis, Membranes, Electrophysiology and ANS (Essay Questions)1.1. Homeostasis1.1.1. Homeostasis Defined1.1.2. Homeostatic Control Systems1.1.3. Feedback Response Loop1.2. Cell Transport; Water & Solutes1.2.1. Fluid Compartments1.2.2. Osmosis1.2.3. Diffusion of Solutes1.2.4. Active Transport1.2.5. Bulk Transport1.3. Electrophysiology1.3.1. Ions and Cell Membranes1.3.2. Membrane Potentials1.3.3. Graded Potential1.3.4. Action Potentials1.3.5. Refractory Periods1.3.6. Propagation of an Action Potential1.4. THE SYNAPSE1.5. THE AUTONOMIC NERVOUS SYSTEM1.5.1. Organization of the Nervous System1.5.2. Structural Organization of the ANS1.5.3. The SNS and the PNS1.5.4. The Enteric Nervous System1.5.5. Physiology of the ANS1.5.6. Neurotransmitters of the ANS1.5.7. Receptors of the ANS1.5.8. Actions of the Autonomic Nervous System1.5.9. Table of Actions for the SNS and PNS and Some Common DrugsModule 2.0. Skeletal Muscle and Special Senses2.1. Structural Organization of Skeletal Muscle2.2.1. Neuromuscular Junction, Excitation-Contraction Coupling2.2.2. Muscle Contractures and Cramps2.3. Whole Muscle Contraction, Fiber Type, Fatigue and Muscle Pharmacology2.3.1. Motor Units2.3.2. Factors that Influence the Force of Contraction2.3.3. Energy Source for Muscle Contraction2.3.4. Skeletal Muscle Fiber Types2.3.5. Fatigue2.3.6. Muscle Pharmacology2.4. Smooth Muscle2.4.1. Smooth Muscle Contraction2.5. Control of Body Movement2.5.1. Voluntary Control of Muscle2.5.2. Reflexes2.6. Taste and Smell2.6.1. Taste2.6.2. The Sense of Smell2.7. Vision2.7.1. Structure of the Eye2.7.2. Focusing Light on the Retina2.7.3. Converting Light to Action Potentials2.7.4. The Retina2.7.5. Phototransduction2.7.6. Receptive Fields2.8. Hearing and Equilibrium2.8.1. The Nature of Sound2.8.2. The Hearing Apparatus2.8.3. Sound Vibrations to Action Potentials2.8.4. The Sense of Balance and EquilibriumModule 3.0. Cardiovascular System3.1. Structure of the Heart3.1.1. Chambers and Circulation3.2. Cardiac Cell Action Potentials3.2.1. Action Potentials in Cardiac Muscle Cells3.2.2. Action Potentials in Cardiac Autorhythmic cells3.2.3. Cellular Mechanisms of Inotropy and Chronotropy3.3. Electrophysiology of Heart Muscle3.3.1. Heart Conduction System3.3.2. Electrocardiogram (ECG)3.3.3. Abnormal ECG - Current of Injury3.4. The Cardiac Cycle3.4.1. Cardiac cycle3.4.2. Cardiac Measurements and Pressure Volume Loops3.5. Blood vessels and Blood Pressure3.5.1. Arteries and Veins3.5.2. Capillaries3.5.3. Blood Pressure Regulation and Shock3.5.4. Capillary Exchange3.5.5. Myogenic and Paracrine Regulation of Vasoconstriction and Vasodilation3.6. Blood3.6.1. Composition of Blood3.6.2. Hematopoeisis3.6.3. Breaking Down Red Blood Cells3.6.4. HemostasisModule 4.0. Urinary and Respiratory Systems4.1. Function and Structure of the Kidney4.1.1. Urinary System Function4.1.2. Functional Anatomy of the Urinary System4.1.3. The Nephron: Functional Unit of the Kidney4.1.4. The Renal Corpuscle: Bowman's Capsule4.2. Physiology of Urine Production4.2.1. Filtration4.2.2. Renal Clearance4.2.3. Tubular Reabsorption4.2.4. Urine Concentration and Dilution4.2.5. Hormonal Regulation of Urine Production4.3. Acid/Base Balance4.3.1. Buffers4.3.2. Acid/Base Disturbances4.4. The Respiratory System4.4.1. Respiratory System Structure and Function4.4.2. Respiratory Membrane4.4.3. Respiratory pressures and Inspriation/Expiration4.4.4. Alveoli and Surfactant4.4.5. Pneumothorax4.5. Gas Exchange and Transport4.5.1. Gas Laws4.5.2. Partial Pressure Gradients in the Lung4.5.3. Alveolar Gas Equation4.5.4. Oxygen and Carbon Dioxide Transport in the Blood4.5.5. Alveolar Ventilation4.5.6. Ventilation/Perfusion Ratio4.6. Chronic Bronchitis and Emphysema4.6.1. Respiratory Control by the Medulla Oblongata4.6.2. Chemicals that Regulate VentilationModule 5.0. Digestive, Endocrine and Reproductive Systems5.1. Functional Anatomy of the Digestive System5.1.1. Layers of the Digestive Tract5.1.2. Enteric Nervous System5.1.3. Organs of the Digestive System5.2. Digestion5.2.1. Carbohydrates5.2.2. Proteins5.2.3. Lipids5.2.4. Lipoproteins5.3. Regulation of Digestive Secretions5.4. Endocrine System5.4.1. Overview of the Endocrine System5.4.2. Hormone Receptors5.4.3. Hormones of the Body5.4.4. Other Hormones: Melatonin and Pheromones5.5. The Hypothalamus and Pituitary Gland5.5.1. Structure and Function of the Hypothalamus and Pituitary Gland5.5.2. The Posterior Pituitary5.5.3. The Anterior Pituitary5.5.4. Growth Hormone5.5.5. Prolactin5.5.6. Thyroid Hormones5.5.7. Adrenal Hormones5.6. Pancreas5.6.1. Insulin and Glucagon5.6.2. Diabetes Mellitus5.7. Reproductive System Anatomy5.7.1. Female Reproductive Anatomy5.7.2. Male Reproductive Anatomy5.7.3. Sexual Development at Puberty5.7.4. Male Reproductive Endocrine Axis5.7.5. Spermatogenesis5.7.6. Female Reproductive System: Oogenesis5.7.7. Ovulation and Fertilization5.7.8. The Ovarian Cycle5.7.9. The Uterine Cycle5.7.10. PregnancyAppendix A. GenderAppendix B. The Placebo EffectB.2.1. The Placebo EffectB.2.2. Examples of the Placebo EffectB.2.3. How do Placebos Work?B.2.4. Are Placebos Ethical?B.2.5. How do we validate actual effectiveness of placebosB.2.6. Tips for evaluating scientific evidenceB.2.7. What about Faith Healings

Electrocardiogram (ECG)

We have been discussing action potentials and how they are generated and conducted through the heart muscle. We have also described their role in triggering contraction of the cardiac muscle. An important technique for diagnosis of problems in the heart is to measure its electrical activity. This is accomplished using an electrocardiograph, which creates a record of the electrical activity of the heart, the electrocardiogram or ECG.

The ECG does not measure individual action potentials but instead it detects the currents flowing through the extracellular fluids, a result of all action potentials, as the charges associated with the heart muscle spread (propagation). Think what happens when you connect a wire between the opposite poles of a battery, current flows through the wire. A similar event is taking place in the extracellular fluids of the body when some of the heart cells are at rest (negative inside and positive outside) while others are depolarized (positive inside and negative outside). When this happens, an electric field is established between opposite charges on the surface of the cardiomyocytes. Sensors placed on the surface of the body can detect changes in the electric field. A tracing can be made of the events taking place during one complete cycle of the heart.

To help you understand how the ECG waves are generated, let’s examine a hypothetical situation in which we have four cells connected end to end. We will explore what happens as an action potential is generated in one cell and then propagates to the other three cells.

Refer to the next figure as we explain the process.

Deflection wave on ECG created as the wave of depolarization moves toward or away from the positive electrode
Drawn by BYU-Idaho student Nathan Shoemaker Fall 2016

In the figure, A-E represents the progression of an action potential beginning with the first cell of the group and then spreading to the next cells. In this example, the positive sensor is placed to the right of the cells and the negative sensor is placed to the left of the cells.

It should be apparent that where one places the electrodes affects the appearance of the ECG tracings. If a wave of depolarization is moving toward a positive electrode there should be a positive deflection. If it is moving away from a positive electrode toward a negative electrode there would be a negative deflection. If the wave is moving perpendicular to an electrode axis then there will be an equal distribution of positive and negative, thus no deflection. How large the deflection is depends both on how closely the wave is oriented to the axis of the electrodes as well as how much of the heart muscle is involved in the depolarization or repolarization. In a typical ECG the electrodes are placed at different positions to give different “looks” of what is happening in the heart.

Wave Deflections based on Vector Directions
Created by BYU-Idaho instructor T. Orton Fall 2017

The difference in deflection on ECG determined by if the wave of depolarization/repolarization is traveling toward or away from the positive electrode. 

Each different positioning of the electrodes is referred to as a different lead and there are 12 leads in a typical ECG.

When all of the electrical events for one cycle are put together we get an ECG tracing.

ECG Tracing
Author: Agateller (Anthony Atkielski).Site:  License: Creative Commons 3.0

The image above shows a typical ECG. Notice that there are several deflections (some up and some down) that occur during the cycle. Each deflection is referred as a wave and each wave is labeled with a letter. A typical ECG has five waves, P, Q, R, S and T. The P wave is generated during depolarization of the atria which causes the atria to contract pushing the blood to the ventricles below. The next three waves (Q, R, S) are generated during depolarization of the ventricles which causes the ventricles to contract forcing the blood out of the heart to the lungs and the rest of the body. Since all are generated during ventricular depolarization we typically refer to these three waves collectively as the QRS complex. The Q wave is the first downward deflection and then back to isoelectric, the R is the large upward deflection and then back to isoelectric, and the S is the second downward deflection and back to isoelectric. The final wave, the T wave, is generated during repolarization of the ventricles. You may be asking yourself where the wave representing repolarization of the atria is. We typically do not observe a repolarization wave for the atria because it is occurring at the same time the ventricles are depolarizing. Since the muscle mass of the ventricles is so much larger than that of the atria, ventricular depolarization probably masks any waves associated with atrial repolarization. Now let’s see if you are getting it. What would the tracing shown in the ECG figure look like if the positive and negative leads were switched?

Hopefully, it is becoming apparent that any change in the heart that affects how the action potential’s spread through the tissues can be detected on the ECG. For example, if a section of heart muscle were damaged by a heart attack the tracing would be altered, usually in a predictable manner. With practice, the physician can diagnose many abnormalities based on the shape and timing of the various waves.

It is important to note that the ECG measures one main thing – the electrical signal as it travels through the heart. It can show if the signal is getting through the conduction fibers as it should or how quickly the heart is beating. In order to measure the strength of the heart you would have to look at several other factors such as: the pressure inside the ventricles at each beat, the resistance of the vessels and/or the volume of blood being ejected with each beat. The figures below illustrate the spread of the action potential across the heart and its associated deflections.

ECG tracing waves explained
Images by JS BYU-Idaho F17

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