CoverModule 1.0. Homeostasis, Membranes, Electrophysiology and ANS (Essay Questions)1.1. Homeostasis1.1.1. Homeostasis Defined1.1.2. Homeostatic Control Systems1.1.3. Feedback Response Loop1.2. Cell Transport; Water & Solutes1.2.1. Fluid Compartments1.2.2. Osmosis1.2.3. Diffusion of Solutes1.2.4. Active Transport1.2.5. Bulk Transport1.3. Electrophysiology1.3.1. Ions and Cell Membranes1.3.2. Membrane Potentials1.3.3. Graded Potential1.3.4. Action Potentials1.3.5. Refractory Periods1.3.6. Propagation of an Action Potential1.4. THE SYNAPSE1.5. THE AUTONOMIC NERVOUS SYSTEM1.5.1. Organization of the Nervous System1.5.2. Structural Organization of the ANS1.5.3. The SNS and the PNS1.5.4. The Enteric Nervous System1.5.5. Physiology of the ANS1.5.6. Neurotransmitters of the ANS1.5.7. Receptors of the ANS1.5.8. Actions of the Autonomic Nervous System1.5.9. Table of Actions for the SNS and PNS and Some Common DrugsModule 2.0. Skeletal Muscle and Special Senses2.1. Structural Organization of Skeletal Muscle2.2.1. Neuromuscular Junction, Excitation-Contraction Coupling2.2.2. Muscle Contractures and Cramps2.3. Whole Muscle Contraction, Fiber Type, Fatigue and Muscle Pharmacology2.3.1. Motor Units2.3.2. Factors that Influence the Force of Contraction2.3.3. Energy Source for Muscle Contraction2.3.4. Skeletal Muscle Fiber Types2.3.5. Fatigue2.3.6. Muscle Pharmacology2.4. Smooth Muscle2.4.1. Smooth Muscle Contraction2.5. Control of Body Movement2.5.1. Voluntary Control of Muscle2.5.2. Reflexes2.6. Taste and Smell2.6.1. Taste2.6.2. The Sense of Smell2.7. Vision2.7.1. Structure of the Eye2.7.2. Focusing Light on the Retina2.7.3. Converting Light to Action Potentials2.7.4. The Retina2.7.5. Phototransduction2.7.6. Receptive Fields2.8. Hearing and Equilibrium2.8.1. The Nature of Sound2.8.2. The Hearing Apparatus2.8.3. Sound Vibrations to Action Potentials2.8.4. The Sense of Balance and EquilibriumModule 3.0. Cardiovascular System3.1. Structure of the Heart3.1.1. Chambers and Circulation3.2. Cardiac Cell Action Potentials3.2.1. Action Potentials in Cardiac Muscle Cells3.2.2. Action Potentials in Cardiac Autorhythmic cells3.2.3. Cellular Mechanisms of Inotropy and Chronotropy3.3. Electrophysiology of Heart Muscle3.3.1. Heart Conduction System3.3.2. Electrocardiogram (ECG)3.3.3. Abnormal ECG - Current of Injury3.4. The Cardiac Cycle3.4.1. Cardiac cycle3.4.2. Cardiac Measurements and Pressure Volume Loops3.5. Blood vessels and Blood Pressure3.5.1. Arteries and Veins3.5.2. Capillaries3.5.3. Blood Pressure Regulation and Shock3.5.4. Capillary Exchange3.5.5. Myogenic and Paracrine Regulation of Vasoconstriction and Vasodilation3.6. Blood3.6.1. Composition of Blood3.6.2. Hematopoeisis3.6.3. Breaking Down Red Blood Cells3.6.4. HemostasisModule 4.0. Urinary and Respiratory Systems4.1. Function and Structure of the Kidney4.1.1. Urinary System Function4.1.2. Functional Anatomy of the Urinary System4.1.3. The Nephron: Functional Unit of the Kidney4.1.4. The Renal Corpuscle: Bowman's Capsule4.2. Physiology of Urine Production4.2.1. Filtration4.2.2. Renal Clearance4.2.3. Tubular Reabsorption4.2.4. Urine Concentration and Dilution4.2.5. Hormonal Regulation of Urine Production4.3. Acid/Base Balance4.3.1. Buffers4.3.2. Acid/Base Disturbances4.4. The Respiratory System4.4.1. Respiratory System Structure and Function4.4.2. Respiratory Membrane4.4.3. Respiratory pressures and Inspriation/Expiration4.4.4. Alveoli and Surfactant4.4.5. Pneumothorax4.5. Gas Exchange and Transport4.5.1. Gas Laws4.5.2. Partial Pressure Gradients in the Lung4.5.3. Alveolar Gas Equation4.5.4. Oxygen and Carbon Dioxide Transport in the Blood4.5.5. Alveolar Ventilation4.5.6. Ventilation/Perfusion Ratio4.6. Chronic Bronchitis and Emphysema4.6.1. Respiratory Control by the Medulla Oblongata4.6.2. Chemicals that Regulate VentilationModule 5.0. Digestive, Endocrine and Reproductive Systems5.1. Functional Anatomy of the Digestive System5.1.1. Layers of the Digestive Tract5.1.2. Enteric Nervous System5.1.3. Organs of the Digestive System5.2. Digestion5.2.1. Carbohydrates5.2.2. Proteins5.2.3. Lipids5.2.4. Lipoproteins5.3. Regulation of Digestive Secretions5.4. Endocrine System5.4.1. Overview of the Endocrine System5.4.2. Hormone Receptors5.4.3. Hormones of the Body5.4.4. Other Hormones: Melatonin and Pheromones5.5. The Hypothalamus and Pituitary Gland5.5.1. Structure and Function of the Hypothalamus and Pituitary Gland5.5.2. The Posterior Pituitary5.5.3. The Anterior Pituitary5.5.4. Growth Hormone5.5.5. Prolactin5.5.6. Thyroid Hormones5.5.7. Adrenal Hormones5.6. Pancreas5.6.1. Insulin and Glucagon5.6.2. Diabetes Mellitus5.7. Reproductive System Anatomy5.7.1. Female Reproductive Anatomy5.7.2. Male Reproductive Anatomy5.7.3. Sexual Development at Puberty5.7.4. Male Reproductive Endocrine Axis5.7.5. Spermatogenesis5.7.6. Female Reproductive System: Oogenesis5.7.7. Ovulation and Fertilization5.7.8. The Ovarian Cycle5.7.9. The Uterine Cycle5.7.10. PregnancyAppendix A. GenderAppendix B. The Placebo EffectB.2.1. The Placebo EffectB.2.2. Examples of the Placebo EffectB.2.3. How do Placebos Work?B.2.4. Are Placebos Ethical?B.2.5. How do we validate actual effectiveness of placebosB.2.6. Tips for evaluating scientific evidenceB.2.7. What about Faith Healings
2.6.1

Taste

Have you ever sat down and eaten something that was just bliss? Perhaps a moist chocolate cake topped with chocolate cream cheese frosting and a fudge filled center, or a marinated chicken breast grilled with roasted red peppers, onions, Portobello mushrooms and Dijon sauce. Some foods have the ability to flood our system with all kinds of different tastes and textures, yet we can sometimes still distinguish the individual contributions of the specific ingredients. This myriad of sensation should not be fully credited to taste because the sense of olfaction and the ability to detect texture are also intimately linked to this perception. In fact, you may have noticed that your mouth is starting to water as you contemplate a plan to obtain the previously mentioned food. The senses of our body-vision, taste, smell, hearing, touch, and equilibrium-are conduits through which we "feel" our world. Each sensory system is uniquely designed with receptors that detect various environmental stimuli and then convert those stimuli to action potentials. That's right; all stimuli that the body detects are ultimately converted to action potentials. In response to the action potential, the brain can interpret and allow us to feel the stimulus. The special senses are those in which their receptors are localized in a specific, fairly small area of the body. In contrast to the special senses, the general senses have receptors that are widespread. The general senses include the sensations of touch, pressure, temperature, pain, and proprioception (movement and position of the body).

Like olfaction, taste (gustation) is a chemical sense responding to different compounds in the foods we eat. It is estimated that humans can distinguish 4000 to 10,000 different chemicals with only five different taste modalities: salt, sweet, bitter, sour, and umami (Japanese for delicious). The receptors responsible for transmitting these taste qualities are located mainly on the dorsal surface of the tongue within structures called taste buds which are housed in epithelial projections called lingual papillae.

Four types of lingual papillae are observed on the human tongue: (1) circumvallate papillae (large groove surrounding the papilla), (2) fungiform papillae (mushroom shaped), (3) foliate papillae (leaf shaped), and (4) filiform papillae (string shaped) so named based on the shapes of each (see image below). Only the circumvallate, fungiform, and foliate papillae contain taste buds; the filiform provide a rough surface for moving food around in the mouth. On average, people have 2000 to 5000 taste buds, but in some exceptional cases, 20,000 have been observed. This has prompted some to propose taste classifications for people that include "non-tasters," "tasters," and "super tasters." Taste, however, is not an all or none phenomenon and the classifications of "non-taster" and "super tasters" simply represent populations of people on opposite ends of the spectrum. Interestingly, some "supertasters" taste and review food for a living and have insured their tasting abilities (job security) for astronomical amounts, like 1 million dollars.

Each taste bud contains 50-150 receptor cells (taste or gustatory cells) sandwiched in between supporting cells and basal cells. Receptor cells are specialized epithelial cells that synapse with neurons. They have the ability to excite their associated neuron when they interact with a taste stimulus, generating action potentials in the neurons. The receptor cells have a relatively short life span and must be replaced about every 10 days. The role of the basal cells in the taste buds is to replace the worn out receptor cells. The taste stimulants (tastants) that react with receptor cells most efficiently are sodium chloride (salty), sucrose (sweet), hydrochloric acid (sour), quinine (bitter) and monosodium glutamate (umami). There is a unique receptor for each of these taste modalities. However, other molecules can also interact with these receptors. For example, artificial sweeteners (e.g., saccharin and aspartame) are known to be 10,000 to 100,000 times more effective than sucrose at stimulating the sweet receptors. Each receptor cell is oriented in the taste bud such that the tip of the cell protrudes into the oral cavity through an opening called a taste pore. This orientation allows the apical end to respond to the tastant and the basal end to transmit the signal to the brain.

As with all sensory systems, taste receptor cells must somehow convert an external or environmental stimulus into an internal or cellular response. In the body, these cellular responses are often associated with changes in membrane potentials. When the receptor is a non-neural cell, as is the case with taste, the depolarization’s are called receptor potentials. The receptor potential is not an action potential but a graded potential that can modulate the activity of ion channels and trigger an action potential in a neuron. Typically the neurons that are associated with taste cells have a resting membrane potential of around -70mV. In order for a response (an action potential) to be generated something has to cause the membrane potential of the neuron to reach threshold. In the case of taste, a neurotransmitter is released from the basal membrane of the taste receptor cell. Release of the neurotransmitter is triggered when a tastant interacts with the apical surface of the receptor cell. This interaction generates a depolarizing receptor potential that causes voltage-gated calcium channels on the basal surface of the cell to open. Calcium diffuses into the cell and acts as a signal to trigger exocytosis, releasing the neurotransmitter onto the neural cells. The neurotransmitter then elicits an action potential in the neuron. Even though different taste receptor cells respond to different tastants, the release of a neurotransmitter from the receptor cells is always caused by an increase in intracellular Ca2+. Thus, to understand how a chemical tastant (external stimulus) results in a neuronal signal (internal response) we need to understand how the tastant can cause a depolarization of the receptor cell and thus an increase in intracellular Ca2+.

For a substance to be tasted, it must first dissolve in the saliva of the mouth. Once dissolved, the substance can interact with the apical membrane of a specific receptor cell. Receptor cells that respond to salt or sour substance contain membrane protein channels that allow the salty ion (Na+) or the sour ion (H+) to pass directly through the channel.

image061.jpg
Signal transduction in a cell in response to a given taste stimulus. 
Image by Jared Cardinet BYU-Idaho Fall 2015

This increased movement of positively charged ions across the membrane causes depolarization which in turn causes voltage sensitive Ca2+ channels to open. Sensations of bitter, sweet and umami all use G-protein coupled receptors, thus, these substances don't cross the membrane, but the effect is still the same (Ca2+ increases in the cell which facilitates the release of neurotransmitter). Molecules that we perceive as bitter, sweet or “savory” (umami) bind as a ligand to G-protein coupled receptors (GPCR). This triggers a second messenger system that results in the opening of Ca2+ channels on the surface of the taste receptor cell or on the smooth endoplasmic reticulum inside the cell (or both).  Ca2+ enters the cytosol and helps trigger the exocytosis of vesicles full of neurotransmitter. 

At least three different properties of the taste sensation pathway allow the brain to distinguish between different taste sensations: (1) the proportion of action potentials received from the different receptor types, (2) additional input from the smell, and (3) additional input from other types of sensory receptors in the mouth. More specifically, foods that contain a higher proportion of salty to sweet chemicals will taste more salty. The sense of smell is very important to our perception of taste. Think of how food tastes when you have a cold and your nasal passageways are congested. Without the input of smell, many foods taste bland, for example, an onion tastes more like an apple. Other input from receptors that detect temperature, texture, and pain enhance the perception of the food. An example of this enhancement is the chemical capsaicin. This chemical is found in varying quantities in different kinds of peppers (measured as scoville units), endowing them with spiciness. However, our perception of spiciness is not the result of activation of a specific taste receptor but is due to the activation of pain receptors. Still, this enhanced taste sensation from capsaicin is a must for many people.

The perception of taste is produced by neural processing within the primary sensory cortex of the brain as it receives action potentials from different nerve bundles. The three major nerves that contribute to gustation are the facial nerve, which receives input from taste receptors located on the anterior two-thirds of the tongue, the glossopharyngeal nerve, associated with the posterior one-third of the tongue, and the vagus nerve, associated with the surface of the epiglottis. All of the nerves converge on the solitary nucleus of the medulla oblongata and eventually arrive at the lateral regions of the primary somatosensory cortex.

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